197 Biotech jobs

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group. The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. The Translational Biology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology. The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders. Responsibilities will include: Leading, executing and driving new Target Identification and Validation initiatives. Ensuring a robust translational framework is embedded early in the project lifetime to drive clear decision making in the clinic. Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs. Depending on experience, may act as the Project Translational lead. Skills and Experience: PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas. Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies. Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging). Strong track record in human and rodent primary immune cell assay development and optimisation. Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research. Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment. Excellent interpersonal, communication and presentation skills and ability to thrive in team setting. Desirable: Hands-on experience in managing outsourced studies with CROs or academic partners. Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial. Interest in metabolic disease or experience working in this area What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group. The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. The Translational Biology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology. The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders. Responsibilities will include: Leading, executing and driving new Target Identification and Validation initiatives. Ensuring a robust translational framework is embedded early in the project lifetime to drive clear decision making in the clinic. Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs. Depending on experience, may act as the Project Translational lead. Skills and Experience: PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas. Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies. Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging). Strong track record in human and rodent primary immune cell assay development and optimisation. Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research. Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment. Excellent interpersonal, communication and presentation skills and ability to thrive in team setting. Desirable: Hands-on experience in managing outsourced studies with CROs or academic partners. Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial. Interest in metabolic disease or experience working in this area What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are recruiting for a Procurement Category Manager, Facilities Management, to join a growing and exciting research facility in Oxford, on a permanent basis. This role will be hybrid, requiring you to be on-site for three days a week. The Company: A research-driven organisation led by talented scientists and entrepreneurs, dedicated to creating sustainable solutions for global challenges through interdisciplinary collaboration. This exciting new campus will feature state of art R&D facility, specialised laboratories, oncology clinics and focus on bridging scientific discovery with real-world applications by integrating expertise from various fields, including biomedical science, engineering, and public health. The Role: Our client is seeking an experienced and commercially savvy Procurement Category Manager, Facilities Management, to oversee Hard and Soft FM services and associated categories such as Laboratory Equipment and Services. Responsibilities: Developing and implementing category strategies for Facilities Management procurement, covering services such as mechanical & electrical (M&E) maintenance, cleaning, security, catering, workplace services, and minor construction works. Managing procurement for subcategories related to Facilities Management, including the sourcing and management of Laboratory Equipment (non-core scientific equipment supporting facilities and operations) and associated technical services. Leading competitive tendering processes, negotiations, supplier selection, and contract award activities, ensuring best value, service quality, and risk mitigation. Building and maintaining strong relationships with internal stakeholders including Facilities teams, Real Estate, Laboratory Managers, Health & Safety, Finance, and Legal departments. Conducting market and supplier analysis to identify opportunities for cost savings, service improvement, innovation, and sustainability. Your Background: Extensive procurement experience, including significant time in Facilities Management sourcing. Experience of procurement of laboratory equipment and services in an FM context. Experience of working in a biotechnology or pharmaceutical company environment. Proven experience of contract negotiation and preparation. A BSc in Procurement, Facilities Management, Supply Chain Management or similar. MCIPS qualified or working towards full membership. Salary: Competitive with an excellent benefits package. Apply : It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCP

CK Group are recruiting for a Shift Senior Site Chemist, to join a hazardous waste management company, based at their site near Birmingham, on a full time, permanent basis, for a salary of up to £32,000 per annum. Please note that this is a shift role, involving nights and working in the outdoors, not in a laboratory. As a Senior Site Chemist, you will be responsible in bringing value to the business, by accepting and inspecting all incoming assignments of Hazardous and Non-Hazardous Waste, by following the relevant regulations and site procedures. This is a role working 40 hpw, Monday- Friday. Location: The site is based near Birmingham and is commutable by Birmingham, Walsall, Wolverhampton, Lichfield and Stafford. As a Senior Site Chemist, the main purpose of your role will be: Ensuring all incoming consignments of wastes have appropriate paperwork. Responsible for the completion of waste safety checks to allow acceptance to site, storage safety and processing and/or onwards transfer. Responsible for the completion of regular sampling of received waste to then further supply to internal laboratory for analysis. Ensuring waste is routed such that costs are minimised whilst maintaining legality and compliance. Waste acceptance is recorded using the SAP system. Ensuring all waste is labelled correctly with all relevant information. Processing of waste as required to include bulking, sorting, segregating, listing and re-packing of wastes. Provide technical support to other members of staff on site. Complete relevant outgoing paperwork. As a Senior Site Chemist, you will have the following qualifications, skills and experience: Degree Level or HNC Qualification in Chemistry or a similar related field. Previous experience of the Waste Industry is essential. SAP experience is essential. Competent Microsoft Office user, in particular Excel. Willingness to work in outdoor conditions in a hazardous chemical environment undertaking a manual/hands on approach. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCH

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group. The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. The Translational Biology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology. The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders. Responsibilities will include: Leading, executing and driving new Target Identification and Validation initiatives. Ensuring a robust translational framework is embedded early in the project lifetime to drive clear decision making in the clinic. Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs. Depending on experience, may act as the Project Translational lead. Skills and Experience: PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas. Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies. Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging). Strong track record in human and rodent primary immune cell assay development and optimisation. Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research. Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment. Excellent interpersonal, communication and presentation skills and ability to thrive in team setting. Desirable: Hands-on experience in managing outsourced studies with CROs or academic partners. Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial. Interest in metabolic disease or experience working in this area What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

CK Group are recruiting for an experienced Analytical Development Scientist, to join a Contract Research & Development and Manufacturing Organisation (CRDMO), working with innovator biotech and pharmaceutical companies globally, who are based in Macclesfield, on a permanent basis. Company: This company is well established and growing with R&D facilities globally. Location: The role is based on site in Macclesfield, Cheshire. Role: Support chemistry projects, through analytical lab-based work, develop, validate and carry out technical transfer of analytical methods and release analysis (GMP and non-GMP). Developing, troubleshooting and validating analytical methods. Planning and executing analytical work to meet project timelines with minimal supervision. Working within multi-functional project teams operating to tight deadlines. Able to work effectively to GMP quality standards. Opportunity to lead the analytical aspects of projects and lead a team of analysts to plan, supervise and execute analytical work to meet project timelines. Your Background: Educated to degree level or above in Chemistry, Analytical Chemistry or a related field. A background in Analytical Chemistry combined with demonstrated in-depth, hands-on expertise in HPLC/GC and experience of other analytical methodologies utilised to characterise APIs, intermediates and raw materials. Experience in other analytical methodologies such as techniques for identity or form determination (e.g. NMR, MS, IR, XRD). Understanding of GMP quality standards. Demonstrated analytical expertise supporting early, mid or late-phase route and process development of APIs, intermediates and raw materials. Experience in contracting analytical testing with third parties and leading communications with customers. Experience in regulatory requirements for the development and validation of LC/GC methods for content and the separation of impurities and degradation products in APIs including trace level analysis. Experience in out of specification and atypical result investigations. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are recruiting for a Laboratory Technician, to join a manufacturing company, that provides products to the agricultural industry, at their site based in Teesside, on a temporary basis for 6 months. The salary for this equates to £26,000 pa. Laboratory Technician main duties: Preparing and analysing exploration drill core samples. Keeping the Laboratory Manager informed of laboratory problems on a day-to-day basis. Developing good relationships with team members and internal customers. Following method statements and risk assessments. Working with other laboratory staff, to determine potential efficiency and performance improvements to workflows within the department. Your Background: The ideal candidate for this role will have the following skills and experience: GCSEs (or equivalent) in Science, Maths and English. Ability to handle large and heavy samples of drill core ( 20 kg) on a regular basis. IOSH Working Safely certificate (desirable). Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCH

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group. The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. The Translational Biology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology. The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders. Responsibilities will include: Leading, executing and driving new Target Identification and Validation initiatives. Ensuring a robust translational framework is embedded early in the project lifetime to drive clear decision making in the clinic. Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs. Depending on experience, may act as the Project Translational lead. Skills and Experience: PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas. Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies. Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging). Strong track record in human and rodent primary immune cell assay development and optimisation. Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research. Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment. Excellent interpersonal, communication and presentation skills and ability to thrive in team setting. Desirable: Hands-on experience in managing outsourced studies with CROs or academic partners. Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial. Interest in metabolic disease or experience working in this area What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are recruiting for a Laboratory Technician, to join a leading global food brand company, on a contract basis for 6 months. Salary: £14.74 per hour PAYE. Laboratory Technician Role: Administer samples for scientific analysis by creating records, assigning analytical tests, allocating samples for analysis. Maintain chain-of-custody for controlled samples. Inputting results and liaising with clients. Perform basic routine pharmacopoeial analysis using aseptic technique under supervision. Perform lab admin and housekeeping duties as directed. Your Background : Scientific background, either through education, technical apprenticeship or equivalent working experience. Time management, prioritisation and organisational skills. Effective verbal and written communication in English. Good written and verbal communication skills. A passion for working in the food industry. Company: Our client is a world leader in food, confectionery and beverages. They operate in over 70 companies worldwide and currently have almost 100,000 talented employees working for them. They have a strong foundation of iconic brands, which makes them a very established company within the field. The client s aim is to have a positive impact on the customers and the planet, while still ensuring business success. Location: This role is based at our clients site in Reading. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. Please note: This role may be subject to a satisfactory basic Disclosure and Barring Service (DBS) check. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news.

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Aspiring Maths Teacher - Secondary School - Swindon - Immediate Start Location: Swindon Start Date: Immediate Contract Type: Full-time, Long-term Daily Rate: £100 - £130 Are you a Maths Graduate eager to kickstart your teaching career? A well-regarded secondary school in Swindon is looking for a passionate and motivated Maths Graduate to join their team immediately click apply for full job details

Role: Men's First Team Sports Scientist Hours: Full-time, to follow the men's first team schedule. To include evenings and weekends. Location: American Express Elite Football Performance Centre, Lancing, BN15 9FP Contract Type: Permanent Deadline Day: 22nd June 2025 About Brighton & Hove Albion FC We compete at the highest levels of football on a global stage while embracing our Sussex community spirit click apply for full job details

Technical Manager (Food) £50'000 - £60'000 (DOE) + Progression + Holiday + Pension + Benefits Monday - Friday Shawbury - Shropshire Are you a Technical Manager from a Food Production / Manufacturing background looking for the next exciting step in your career with a well-established forward thinking company? This well-established, family run company have built a great reputation over the year click apply for full job details

Role:- Agrochemical Technical Manager Location: Ellesmere Port- onsite (with some flexibility) and 20% travel (domestic and international travel) Salary & Benefits:- Highly competitive salary (DOE), Pension Up to 10% EE/15% ER, annual bonus, Death in service x 6, private medical insurance, 25 days annual leave which increases with length of service up to 28 & sharesave scheme click apply for full job details

CK Group are recruiting for a temporary Laboratory Technician, on behalf of a leading multinational producer of household plastic products, on a fixed term contract basis of 3 months. This is a full time position, 35.5 hours per week. Monday to Thursday: 9am - 5pm, Friday: 9am - 3pm, based at their site in Cramlington. Salary: Approximately £28,000 per annum (pro-rata for a 3 month contract). Your main duties will be: Carrying out laboratory testing of materials and samples. Recording and reporting test results. Candidate requirements - skills and experience: Degree/HND/HNC in Chemistry, Materials Science or a related field. Experience working in a laboratory. Must have a full UK Driving Licence, be able to drive and have access to a car. Apply: It is essential that applicants hold entitlement to work in the UK. Must have a full UK Driving Licence, be able to drive and have access to a car. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCH

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are recruiting for a Site Chemist, to join a Hazardous Waste Management company, at their site based in the West Midlands, on a full time, permanent basis for a salary of £26,000. As a Site Chemist, you will accept and inspect all incoming assignments of Hazardous and Non-Hazardous Waste, by following the relevant regulations and site procedures. The role will involve working 40 hours per week, 8am - 5pm, Monday - Friday. Please note this role will be based outdoors and indoors. Location : The Site Chemist will be based at the company's site near Walsall and is commutable from Birmingham, Wolverhampton, Stafford and Coventry. Site Chemist Role : As a Site Chemist the main purpose of your role will be: Labelling and processing waste. Completing waste safety checks. Sampling of received waste for internal laboratory analysis. Using SAP system to record waste acceptance. As a Site Chemist, you will have the following qualifications, skills and experience: Degree or HNC Qualification in Chemistry or a similar related field - essential. Experience of working with Hazardous Waste - essential. Willingness to work hands-on, outdoors, in a hazardous chemical environment - essential. SAP experience - desirable. FLT Licence holder (Forklift) - desired. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCH

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group. The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. The Translational Biology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology. The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders. Responsibilities will include: Leading, executing and driving new Target Identification and Validation initiatives. Ensuring a robust translational framework is embedded early in the project lifetime to drive clear decision making in the clinic. Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs. Depending on experience, may act as the Project Translational lead. Skills and Experience: PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas. Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies. Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging). Strong track record in human and rodent primary immune cell assay development and optimisation. Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research. Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment. Excellent interpersonal, communication and presentation skills and ability to thrive in team setting. Desirable: Hands-on experience in managing outsourced studies with CROs or academic partners. Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial. Interest in metabolic disease or experience working in this area What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDLS

Tech BD Manager - Teleco Solutions for Hospitality Field based (Onsite as required) Up to £65,000 base depending on experience with OTE My client is seeking an experienced, driven, and strategic Senior Business Development Manager to lead their growth efforts in the hospitality sector, focusing on delivering innovative teleco solutions to hotels, resorts, and hospitality groups click apply for full job details

Job Title: Senior Laboratory Research Scientist - Specialist Virology Researcher (SLRS) Details of the role : Full-time, permanent. Working pattern: Monday - Friday. Salary : From £45,7000 pa with benefits, subject to skills and experience Application closing date : 23/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Over the first year of the COVID-19 pandemic, the Crick developed a range of COVID-19 research platforms, including a unique high throughput live virus assay platform to quantify neutralising antibody activity against a range of SARS-CoV-2 variants in thousands of samples simultaneously. In collaboration with both clinical researchers and the Worldwide Influenza Centre (WIC) based at the Crick, we have used our microneutralisation platform to show at large scale how immunity to COVID-19 following vaccination and infection differs between healthy adults and clinically vulnerable patients. The Crick's COVID Surveillance Unit (CSU) was created in 2021 to run and improve upon this high-throughput live-virus assay pipeline. We are seeking to appoint a talented, collaborative, and self-motivated scientist to fill a full-time on-site laboratory position within the COVID Surveillance Unit (CSU) team. The team is responsible for the day to day running of a microneutralisation assay pipeline and you will either be capable of, or be willing to learn, all aspects of the pipeline to contribute to a dynamic and fluid team. You will need to horizon scan in the development of future assay platforms by interacting with Crick and external researchers and maintaining up to date knowledge of high-throughput technologies, virological and immunological techniques and advances. This is an opportunity to use your scientific and technical skills in a clinically vital enterprise and shape its development with your knowledge and expertise within one of the largest research institutes in Europe. What you will be doing As an SLRS at the Crick, you will: Ensuring the smooth operation of the neutralisation assay pipeline by conducting assays to the highest standards, liaising with all interested parties and team members ensuring clear communication. Managing workflows and ensuring neutralisation data is generated in a timely manner agreed with end users. The team must be adaptable and flexible in order to quickly adjust ongoing scheduled work to accommodate the unexpected. Providing experimental or technical support/assistance to other team members, and provide expertise feedback/input for the development, refinement, and troubleshooting of existing and novel methodologies. Isolation, propagation and genetic/molecular characterisation of newly emerging and reference SARS-CoV-2 and seasonal influenza viruses Managing and generating stocks of pseudoviruses and RG viruses for the neutralisation assay pipeline Applying understanding of the assay pipeline to adapting and/or developing new high throughput virological and immunological assays. Undertaking own research project, designing, and executing experiments /with strategic direction from the group head. About you The essential criteria you will bring PhD or equivalent qualification/experience in virology, immunology, or high throughput methodologies Extensive direct experience in cell-based assays, tissue culture, and immunofluorescence-staining techniques Previous experience in working with respiratory viruses, pseudoviruses, and RG viruses Previous experience in working with immunoassays Practical experience with a wide range of molecular and cell biology techniques Experience with data analysis and visualisation using R and/or Python To see the complete job description, click here . To learn more about team click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

CK Group are recruiting for a Shift Senior Site Chemist, to join a hazardous waste management company, based at their site near Birmingham, on a full time, permanent basis, for a salary of up to £32,000 per annum. Please note that this is a shift role, involving nights and working in the outdoors, not in a laboratory. As a Senior Site Chemist, you will be responsible in bringing value to the business, by accepting and inspecting all incoming assignments of Hazardous and Non-Hazardous Waste, by following the relevant regulations and site procedures. This is a role working 40 hpw, Monday- Friday. Location: The site is based near Birmingham and is commutable by Birmingham, Walsall, Wolverhampton, Lichfield and Stafford. As a Senior Site Chemist, the main purpose of your role will be: Ensuring all incoming consignments of wastes have appropriate paperwork. Responsible for the completion of waste safety checks to allow acceptance to site, storage safety and processing and/or onwards transfer. Responsible for the completion of regular sampling of received waste to then further supply to internal laboratory for analysis. Ensuring waste is routed such that costs are minimised whilst maintaining legality and compliance. Waste acceptance is recorded using the SAP system. Ensuring all waste is labelled correctly with all relevant information. Processing of waste as required to include bulking, sorting, segregating, listing and re-packing of wastes. Provide technical support to other members of staff on site. Complete relevant outgoing paperwork. As a Senior Site Chemist, you will have the following qualifications, skills and experience: Degree Level or HNC Qualification in Chemistry or a similar related field. Previous experience of the Waste Industry is essential. SAP experience is essential. Competent Microsoft Office user, in particular Excel. Willingness to work in outdoor conditions in a hazardous chemical environment undertaking a manual/hands on approach. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news. INDCH